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There are no randomized controlled trials that compare the 2 modes of therapy

Orlistat (Alli, Xenical) Phentermine and topiramate (Qsymia) Naltrexone and bupropion (Contrave) If you have severe obesity and are unable to achieve your weight loss goals on Wegovy or other weight loss drugs, talk with your doctor about surgical options for long-term weight management, such as bariatric surgery

However, the widespread adoption of HDTs requires further validation through large-scale clinical trials to establish their efficacy, safety, and cost-effectiveness in diverse populations

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